Four people are dead and two injured in a crash on Loop 335 Near Broadway Drive, Wednesday night.
Amarillo police say possible intoxication may have been involved when an eastbound pickup truck was traveling the wrong way on the road and struck a westbound Nissan Altima.
A 23 year old and the driver of the suspect vehicle were transported to the hospital with life-threatening injuries.
Amarillo Police, Fire, and Potter County Fire all responded to the crash.
The wreck is under investigation by the AmarilloPolice Traffic Investigation Unit.